HIV Combo Dolutagravir, Lamivudine and Tenofivir

Dolutegravir, Lamivudine, and Tenofovir combination is often prescribed as a once-daily regimen for the treatment of HIV-1 infection in adults and pediatric patients. Here are some details on each component:

Dolutegravir (DTG):Class: Integrase Strand Transfer Inhibitor (INSTI)Mechanism of Action: Inhibits the integrase enzyme, preventing integration of viral DNA into the host genome.

Efficacy: Potent antiretroviral activity with a high barrier to resistance.

Dosage: Usually taken once daily.

Lamivudine (3TC):Class: Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Mechanism of Action: Inhibits the reverse transcriptase enzyme, preventing viral RNA to DNA conversion.

Efficacy: Effective against HIV-1 and hepatitis B virus.

Dosage: Typically taken once daily.

Tenofovir (TDF or TAF):Class: Nucleotide Reverse Transcriptase Inhibitor (NRTI)

Mechanism of Action: Inhibits reverse transcriptase like lamivudine, but as a nucleotide, it requires less intracellular conversion.

TDF vs. TAF: Tenofovir is available as tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF). TAF has a more favorable renal and bone safety profile.

Dosage: Once daily for both TDF and TAF.

Advantages of the combination:High antiviral efficacy.Simplified dosing (once daily).Generally well-tolerated.Low risk of drug interactions.

Considerations:Adherence to the prescribed regimen is crucial for optimal treatment outcomes.Regular monitoring of viral load and CD4 count is essential.Potential side effects include nausea, headache, and mild renal effects (especially with TDF).

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